Changes in S100B and troponin levels in a fetal sheep model of worsening acidosis

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Ould Hamoud, Yasmine | Pekar, J. D. | Drumez, Elodie | Lacan, Laure | Maboudou, Patrice | de Jonckheere, Julien | Storme, Laurent | Debarge, Veronique | Sharma, Dyuti | Garabedian, Charles | Ghesquière, Louise

Edité par CCSD ; Elsevier -

International audience. BackgroundS100B and cardiac troponin T (c-TnT) are relevant biomarkers at birth of hypoxic-ischemic encephalopathy (HIE) and myocardial ischemia secondary to metabolic acidosis during labor, respectively. The purpose was to assess in-utero changes in S100B and c-TnT levels in an experimental model of labor-like acidosis.MethodsRepeated umbilical cord occlusions (UCOs) in ten experiments were performed in mild (phase A, 1 UCO/5 mn), moderate (phase B, 1 UCO/3 mn), and severe (phase C, 1 UCO/2 mn) period. The experiments were stopped if arterial pH reached 6.90.ResultsUCOs resulted in fetal acidosis with pH dropping to 6.99 ±0.13. When compared to the baseline period fetal S100B increased between phases A and B (7% ± 4 vs 17% ± 13, p = 0.030) and between phases A and C (7% ± 4 vs 24% ± 8, p < 0.001). Fetal c-TnT serum levels increased during occlusions: 102 ng/L (58–119) in phase A, vs 119 ng/L (103–198) in phase B vs 169 ng / L (128–268) in phase C (p < 0.05, for all). When compared to the baseline control period, fetal ΔcTnT was significantly modified throughout UCO series: 5.0% (-3; 45) in phase A, 51% (4; 263) in phase B, and 77% (56.5; 269) in phase C (p < 0.05 for all).ConclusionsS100B and c-TnT increased when fetal acidosis occurred, which reflects the potential neurological damage and fetal cardiovascular adaptation.Keywords

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