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Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants

Archive ouverte | Hegron, Alan | CCSD

International audience. Melatonin is a hormone mainly produced by the pineal gland and MT1 is one of the two G protein-coupled receptors (GPCRs) mediating its action. Despite an increasing number of available GPCR c...

Type 2 diabetes–associated variants of the MT 2 melatonin receptor affect distinct modes of signaling

Archive ouverte | Karamitri, Angeliki | CCSD

International audience. Connecting melatonin receptor variants to signaling differences reveals paths to type 2 diabetes therapy.

Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity

Archive ouverte | Gao, Wenwen | CCSD

International audience. The glucagon-like peptide 1 receptor (GLP1R) is a major drug target with several agonists being prescribed in individuals with type 2 diabetes and obesity 1,2. The impact of genetic variabili...

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