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Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension

Archive ouverte | Le Ribeuz, Hélène | CCSD

International audience. Aims: We hypothesized that the ATP-sensitive K+ channels (KATP) regulatory subunit (ABCC9) contributes to PAH pathogenesis. ABCC9 gene encodes for two regulatory subunits of KATP channels: th...

Pulmonary hypertension associated with diazoxide: the SUR1 paradox

Archive ouverte | Montani, David | CCSD

International audience. The ATP-sensitive potassium channels and their regulatory subunits, sulfonylurea receptor 1 (SUR1/Kir6.2) and SUR2/Kir6.1, contribute to the pathophysiology of pulmonary hypertension (PH). Lo...

Implication of Potassium Channels in the Pathophysiology of Pulmonary Arterial Hypertension

Archive ouverte | Le Ribeuz, Hélène | CCSD

International audience. Pulmonary arterial hypertension (PAH) is a rare and severe cardiopulmonary disease without curative treatments. PAH is a multifactorial disease that involves genetic predisposition, epigeneti...

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