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DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability

Archive ouverte | Ben Yamin, Barbara | CCSD

International audience. The DNA polymerase zeta (Polf) plays a critical role in bypassing DNA damage. REV3L, the catalytic subunit of Polf, is also essential in mouse embryonic development and cell proliferation for...

Functional Assessment of Genetic Variants with Outcomes Adapted to Clinical Decision-Making

Archive ouverte | Thouvenot, Pierre | CCSD

International audience. Understanding the medical effect of an ever-growing number of human variants detected is a long term challenge in genetic counseling. Functional assays, based on in vitro or in vivo evaluatio...

Yeast cells reveal the misfolding and the cellular mislocalisation of the human BRCA1 protein

Archive ouverte | Thouvenot, Pierre | CCSD

International audience. Understanding the effect of an ever-growing number of human variants detected by genome sequencing is a medical challenge. The yeast Saccharomyces cerevisiae model has held attention for its ...

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