Afficher la couverture 'The metabolome of human milk is altered differentially by Holder pasteurization and high hydrostatic pressure processing. | Tran, Léa Chantal' en grand format
/5

0 avis

The metabolome of human milk is altered differentially by Holder pasteurization and high hydrostatic pressure processing.

Archive ouverte

Tran, Léa Chantal | Marousez, Lucie | de Lamballerie, Marie | Mcculloch, Scott | Hermann, Emmanuel | Gottrand, Fréderic | Ley, Delphine | Lesage, Jean

Edité par CCSD ; Frontiers Media S.A. -

International audience. The milk metabolome is composed of hundreds of molecules that can impact infant development. In preterm infants, sterilized donor milk (DM) is frequently used for their feeding. We aimed to identify differences in the metabolome of DM after two types of milk sterilization: the Holder pasteurization (HoP) and a high hydrostatic pressure (HP) processing. DM samples were sterilized by HoP (62.5°C for 30 min) or processed by HP (350 MPa at 38°C). 595 milk metabolites were analyzed using an untargeted metabolomic analysis. Both treatments differentially altered several classes of compounds. The major changes noted included decreased levels of free fatty acids, phospholipid metabolites, and sphingomyelins. Decreases were more strongly noted in HP samples rather than in HoP ones. Both HoP and HP treatments increased the levels of ceramides and nucleotide compounds. The sterilization of human milk altered its metabolome especially for lipids.

Suggestions

Du même auteur

Short-chain fatty acids levels in human milk are not affected by holder pasteurization and high hydrostatic pressure processing

Archive ouverte | Marousez, Lucie | CCSD

International audience. Sterilized donor milk (DM) is frequently used for feeding preterm infants. To date, the effect of different modes of DM sterilization on short-chain fatty acids (SCFAs) remains unknown. We ai...

Prebiotic Supplementation during Lactation Affects Microbial Colonization in Postnatal-Growth-Restricted Mice.

Archive ouverte | Marousez, Lucie | CCSD

International audience. Background: An inadequate perinatal nutritional environment can alter the maturation of the intestinal barrier and promote long-term pathologies such as metabolic syndrome or chronic intestin...

High hydrostatic pressure is similar to Holder pasteurization in preserving donor milk antimicrobial activity

Archive ouverte | Tran, Léa Chantal | CCSD

International audience. BackgroundThe microbiological safety of donor milk (DM) is commonly ensured by Holder pasteurization (HoP, 62.5 °C for 30 min) in human milk banks despite its detrimental effects on bioactive...

Chargement des enrichissements...