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Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protection

Archive ouverte | Alexandre, Marie | CCSD

International audience. The definition of correlates of protection is critical for the development of next generation SARS-CoV-2 vaccine platforms. Here, we propose a new framework for identifying mechanistic correl...

Targeting SARS-CoV-2 receptor-binding domain to cells expressing CD40 improves protection to infection in convalescent macaques

Archive ouverte | Marlin, Romain | CCSD

International audience. Abstract Achieving sufficient worldwide vaccination coverage against SARS-CoV-2 will require additional approaches to currently approved viral vector and mRNA vaccines. Subunit vaccines may h...

Targeting human langerin promotes HIV-1 specific humoral immune responses

Archive ouverte | Kervevan, Jérôme | CCSD

International audience. The main avenue for the development of an HIV-1 vaccine remains the induction of protective antibodies. A rationale approach is to target antigen to specific receptors on dendritic cells (DC)...

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