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Host prion protein expression levels impact prion tropism for the spleen

Archive ouverte | Béringue, Vincent | CCSD

International audience. Prions are pathogens formed from abnormal conformers (PrPSc) of the host-encoded cellular prion protein (PrPC). PrPSc conformation to disease phenotype relationships extensively vary among pr...

Mutated but not deleted ovine PrPCN-terminal polybasic region strongly interferes with prion propagation in transgenic mice

Archive ouverte | Khalife, Manal | CCSD

Mammalian prions are proteinaceous infectious agents composed of misfolded assemblies of the host-encoded, cellular prion protein (PrP). Physiologically, the 23-31 N-terminal polybasic region of PrP has been shown to be involved i...

Optimization and evaluation of new decontamination procedures inactivating human prions

Archive ouverte | Herzog, Laetitia | CCSD

International audience. BackgroundPrions are protein-only infectious agents for which no prophylactic or curative treatment exists. Infectivity bioassays based on hamster-263K prions allowed to identify processes ca...

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