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Quaternary structural convergence and structural diversification of prion assemblies at the early replication stage

Archive ouverte | Igel-Egalon, Angélique | CCSD

Abstract Aggregation of misfolded forms from host-encoded proteins is key to the pathogenesis of a number of neurodegenerative disorders, including prion diseases, Alzheimer’s disease and Parkinson’s disease. In prion diseases, th...

Early stage prion assembly involves two subpopulations with different quaternary structures and a secondary templating pathway

Archive ouverte | Igel-Egalon, Angélique | CCSD

International audience. The dynamics of aggregation and structural diversification of misfolded, host-encoded proteins in neurodegenerative diseases are poorly understood. In many of these disorders, including Alzhe...

Process of structural diversification and synergy between prion subassemblies during host adaptation

Archive ouverte | Egalon, Angelique | CCSD

International audience. In prion diseases, the cellular prion protein PrPC can misfold into PrPSc and auto-organize into conformationally distinct assemblies or strains. A plethora of observations reports the existe...

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