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A seven-residue deletion in PrP leads to generation of a spontaneous prion formed from C-terminal C1 fragment of PrP

Archive ouverte | Munoz-Montesino, Carola | CCSD

International audience. Prions result from a drastic conformational change of the host-encoded cellular prion protein (PrP), leading to the formation of β-sheet-rich, insoluble, and protease-resistant self-replicati...

Generating Bona Fide Mammalian Prions with Internal Deletions

Archive ouverte | Munoz Montesino, Carola | CCSD

International audience. Mammalian prions are PrP proteins with altered structures causing transmissible fatal neurodegenerative diseases. They are self-perpetuating through formation of beta-sheet-rich assemblies th...

Deletion of the C-terminal part of helix alpha 2 does not prevent the prion conversion

Archive ouverte | Munoz Montesino, Carola | CCSD

International audience

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