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Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics

Archive ouverte | Huck, Volker | CCSD

International audience. Abstract The multimeric plasma glycoprotein (GP) von Willebrand factor (VWF) is best known for recruiting platelets to sites of injury during primary hemostasis. Generally, mutations in the V...

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Archive ouverte | Schneppenheim, Reinhard | CCSD

International audience. Abstract The frequent von Willebrand factor (VWF) variant p.Phe2561Tyr is located within the C4 domain, which also harbors the platelet GPIIb/IIIa-binding RGD sequence. To investigate its pot...

Structure and dynamics of the platelet integrin-binding C4 domain of von Willebrand factor

Archive ouverte | Xu, Emma-Ruoqi | CCSD

International audience. Abstract Von Willebrand factor (VWF) is a key player in the regulation of hemostasis by promoting recruitment of platelets to sites of vascular injury. An array of 6 C domains forms the dimer...

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