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Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes accelerates the development of myelofibrosis

Archive ouverte | Duparc, Hélène | CCSD

International audience. No abstract available

ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis

Archive ouverte | Basso-Valentina, Francesca | CCSD

International audience. Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes thrombocytopenia 2 (THC2), an inherited platelet disorder associated with a predisposition to leukemia. Some pat...

Dual role of EZH2 in megakaryocyte differentiation

Archive ouverte | Mazzi, Stefania | CCSD

International audience. EZH2 inhibition accelerates MK differentiation. EZH2 regulates polyploidization and proplatelet formation. EZH2, the enzymatic component of PRC2, has been identified as a key factor in hemato...

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