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Hypothalamic bile acid-TGR5 signaling protects from obesity

Archive ouverte | Castellanos-Jankiewicz, Ashley | CCSD

International audience. Bile acids (BAs) improve metabolism and exert anti-obesity effects through the activation of the Takeda G protein-coupled receptor 5 (TGR5) in peripheral tissues. TGR5 is also found in the br...

Single cell tracing of Pomc neurons reveals recruitment of ‘Ghost’ subtypes with atypical identity in a mouse model of obesity

Archive ouverte | Leon, Stéphane | CCSD

International audience. The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling hypothalamic f...

Functional heterogeneity of POMC neurons relies on mTORC1 signaling

Archive ouverte | Saucisse, Nicolas | CCSD

International audience. Hypothalamic pro-opiomelanocortin (POMC) neurons are known to trigger satiety. However, these neuronal cells encompass heterogeneous subpopulations that release γ-aminobutyric acid (GABA), gl...

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