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Evaluation of 18 F-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue

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Lepelletier, François-Xavier | Vandesquille, Matthias | Asselin, Marie-Claude | Prenant, Christian | Robinson, Andrew, C | Mann, David, M A | Green, Michael | Barnett, Elizabeth | Banister, Samuel, D | Mottinelli, Marco | Mesangeau, Christophe | Mccurdy, Christopher, R | Fricke, Inga, B | Jacobs, Andreas, H | Kassiou, Michael | Boutin, Hervé

Edité par CCSD ; Ivyspring International Publisher -

International audience. This work shows that 18 F-IAM6067 is a specific and selective S1R radiotracer. The absence or small changes in S1R detected here in animal models and human tissue warrants further investigations and suggests that S1R might not be the anticipated ideal biomarker for neuronal loss in neurodegenerative diseases such as AD and PD.

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