Afficher la couverture 'Calreticulin contributes to C1q-dependent recruitment of microglia in the leech Hirudo medicinalis following a CNS injury | Le Marrec-Croq, Francoise' en grand format
/5

0 avis

Calreticulin contributes to C1q-dependent recruitment of microglia in the leech Hirudo medicinalis following a CNS injury

Archive ouverte

Le Marrec-Croq, Francoise | Bocquet-Garcon, Annelise | Vizioli, Jacopo | Vancamp, Christelle | Drago, Francesco | Franck, Julien | Wisztorski, Maxence | Salzet, Michel | Sautiere, Pierre-Eric | Lefebvre, Christophe

Edité par CCSD ; Medical Science International Publishing -

International audience. The medicinal leech is considered as a complementary and appropriate model to study immune functions in the central nervous system (CNS). In a context in which an injured leech's CNS can naturally restore normal synaptic connections, the accumulation of microglia (immune cells of the CNS that are exclusively resident in leeches) has been shown to be essential at the lesion to engage the axonal sprouting. HmC1q (Hm for Hirudo medicinalis) possesses chemotactic properties that are important in the microglial cell recruitment by recognizing at least a C1q binding protein (HmC1qBP alias gC1qR).

Consulter en ligne

Suggestions

Du même auteur

ALK4/5-dependent TGF-β signaling contributes to the crosstalk between neurons and microglia following axonal lesion

Archive ouverte | Raffo-Romero, Antonella | CCSD

International audience. Neuronal activity is closely influenced by glia, especially microglia which are the resident immune cells in the central nervous system (CNS). Microglia in medicinal leech are the only cells ...

Medicinal Leech CNS as a Model for Exosome Studies in the Crosstalk between Microglia and Neurons

Archive ouverte | Raffo-Romero, Antonella | CCSD

WOS:000455323500426. International audience. In healthy or pathological brains, the neuroinflammatory state is supported by a strong communication involving microglia and neurons. Recent studies indicate that extrac...

Modulation properties of factors released by bone marrow stromal cells on activated microglia: an in vitro study

Archive ouverte | Cizkova, Dasa | CCSD

International audience. Abstract In the present paper we develop a new non-cell based (cell-free) therapeutic approach applied to BV2 microglial cells and spinal cord derived primary microglia (PM) using conditioned...

Chargement des enrichissements...