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Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver

Archive ouverte | Dubois, Vanessa | CCSD

International audience. Liver injury triggers adaptive remodeling of the hepatic transcriptome for repair/regeneration. We demonstrate that this involves particularly profound transcriptomic alterations where acute ...

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity Of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice

Archive ouverte | Pourcet, Benoit | CCSD

International audience. BACKGROUND & AIMS:The innate immune system responds not only to bacterial signals, but also to non-infectious danger-associated molecular patterns that activate the NLRP3 inflammasome complex...

Differential Unfolded Protein Response in skeletal muscle from non-diabetic glucose tolerant or intolerant patients with obesity before and after bariatric surgery

Archive ouverte | Marciniak, Camille | CCSD

International audience. AIMS:Not all people with obesity become glucose intolerant, suggesting differential activation of cellular pathways. The unfolded protein response (UPR) may contribute to the development of i...

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