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Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Archive ouverte | Pecquet, Christian | CCSD

International audience. Abstract Calreticulin (CALR) +1 frameshift mutations in exon 9 are prevalent in myeloproliferative neoplasms. Mutant CALRs possess a new C-terminal sequence rich in positively charged amino a...

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Archive ouverte | Pecquet, Christian | CCSD

International audience. Abstract Mutant calreticulin (CALR) proteins resulting from a −1/+2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myelopr...

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis

Archive ouverte | Pasquier, Florence | CCSD

International audience

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