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Myeloablative and reduced-intensity conditioned allogeneic haematopoietic stem cell transplantation in myelofibrosis: a retrospective study by the chronic malignancies working party of ebmt

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Mclornan, Donal | Szydlo, Richard | Koster, Linda | Chalandon, Yves | Robin, Marie | Wolschke, Christine | Beelen, Dietrich | Socie, Gerard | Bornhauser, Martin | Angelucci, Emanuele | Niederwieser, Dietger | Gerbitz, Arnim | Finke, Jurgen | Vitek, Antonin | Itala-Remes, Maija | Radujkovic, Aleksandar | Kanz, Lothar | Potter, Victoria | Chevallier, Patrice | Stelljes, Matthias | Petersen, Eefke | Robinson, Stephen | Poire, Xavier | Klyuchnikov, Evgeny | Hernandez-Boluda, Juan Carlos | Czerw, Tomasz | Hayden, Patrick | Kroger, Nicolaus | Yakoub-Agha, Ibrahim

Edité par CCSD ; Elsevier -

International audience. This retrospective study by the European Society for Blood and Marrow Transplantation analyzed the outcome of 2224 patients with myelofibrosis (MF) who underwent allogeneic stem cell transplantation (allo-SCT) between 2000 and 2014; 781 (35%) underwent myeloablative conditioning (MAC) and 1443 (65%) reduced-intensity conditioning (RIC). Median patient age was 52.9 years (range, 18 to 74 years) and 57.5 years (range, 21 to 76 years) in the MAC and RIC cohorts, respectively. Donor type was similar: matched sibling donors (MAC, 317 [41%]; RIC, 552 [38%]) and unrelated donors (MAC, 464 [59%]; RIC, 891 [62%]). Median time to both neutrophil and platelet (>20 × 109

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