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Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks

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Mojumdar, Aditya | Sorenson, Kyle | Hohl, Marcel | Toulouze, Mathias | Lees-Miller, Susan, P | Dubrana, Karine | Petrini, John, H J | Cobb, Jennifer, A

Edité par CCSD ; Elsevier Inc -

International audience. Highlights d The MRX complex stabilizes Nej1 at the break site d Nej1 inhibits Dna2 recruitment and HR d Nej1 and the coiled-coil region of Rad50 are important for tethering broken DNA ends d Defects in 5 0 resection and end-tethering lead to large chromosome deletions at the DSB Authors

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