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Description of a European memory clinic cohort undergoing amyloid‐PET: The AMYPAD Diagnostic and Patient Management Study

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Altomare, Daniele | Collij, Lyduine | Caprioglio, Camilla | Scheltens, Philip | van Berckel, Bart, N M | Alves, Isadora, Lopes | Berkhof, Johannes | de Gier, Yvonne | Garibotto, Valentina | Moro, Christian | Poitrine, Léa | Delrieu, Julien | Payoux, Pierre | Saint‐Aubert, Laure | Molinuevo, José, Luis | Grau‐rivera, Oriol | Gispert, Juan‐domingo | Minguillón, Carolina | Fauria, Karine | Sanchez, Marta, Felez | Rădoi, Andreea | Drzezga, Alexander | Jessen, Frank | Escher, Claus | Zeyen, Philip | Nordberg, Agneta | Savitcheva, Irina | Jelic, Vesna | Walker, Zuzana | Lee, Ho‐yun | Lee, Lean | Demonet, Jean‐françois | Plaza Wuthrich, Sonia | Gismondi, Rossella | Farrar, Gill | Barkhof, Frederik | Stephens, Andrew, W | Frisoni, Giovanni, B

Edité par CCSD ; Alzheimer's Association / Wiley -

International audience. Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the representativeness of the cohort.Methods: Participants with subjective cognitive decline plus (SCD+), mild cognitive impairment (MCI), or dementia were recruited in eight European memory clinics from April 16, 2018, to October 30, 2020, and randomized into three arms: ARM1, early amyloid-PET; ARM2, late amyloid-PET; and ARM3, free-choice.Results: A total of 840 participants (244 SCD+, 341 MCI, and 255 dementia) were enrolled. Sociodemographic/clinical features did not differ significantly among recruiting memory clinics or with previously reported cohorts. The randomization assigned 35% of participants to ARM1, 32% to ARM2, and 33% to ARM3; cognitive stages were distributed equally across the arms.Discussion: The features of AMYPAD-DPMS participants are as expected for a memory clinic population. This ensures the generalizability of future study results.

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