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Transformed cells after senescence give rise to more severe tumor phenotypes than transformed non-senescent cells

Archive ouverte | Palazzo, Alberta | CCSD

International audience. Oncogenic stress-induced senescence initially inhibits tumor initiation by blocking proliferation and by attracting immune cells to clear potentially harmful cells. If these cells are not eli...

A non-canonical role of ELN protects from cellular senescence by limiting iron-dependent regulation of gene expression

Archive ouverte | Czarnecka-Herok, Joanna | CCSD

International audience. The ELN gene encodes tropoelastin which is used to generate elastic fibers that insure proper tissue elasticity. Decreased amounts of elastic fibers and/or accumulation of bioactive products ...

PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging

Archive ouverte | Huna, Anda | CCSD

International audience. Although aging is a major risk factor for most types of cancers, it is barely studied in this context. The transmembrane protein PLA2R1 (phospholipase A2 receptor) promotes cellular senescenc...

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