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Prognostic Value of KIT Exon 11 Deletions in GISTs

Archive ouverte | Emile, Jean-François | CCSD

International audience. Abstract Purpose: Gastrointestinal stromal tumors (GIST) are frequently associated with gain-of-function mutations of KIT, which can be inhibited by imatinib both in vitro and in vivo. The su...

Effects of endoplasmic reticulum stressors on maturation and signaling of hemizygous and heterozygous wild‐type and mutant forms of KIT

Archive ouverte | Brahimi-Adouane, Sabrina | CCSD

International audience. Gain of function mutations of KIT are frequent in some human tumors, and are sensible to tyrosine kinase inhibitors. In most tumors, oncogenic mutations are heterozygous, however most in vitr...

Colorectal neuroendocrine carcinomas and adenocarcinomas share oncogenic pathways. A clinico-pathologic study of 12 cases

Archive ouverte | Karkouche, Raymond | CCSD

International audience. OBJECTIVE:Neuroendocrine carcinomas (NECs) are rare neoplasms with an increasing incidence. Oncogenetic pathways of colorectal NEC are still poorly understood, and no treatment standards are ...

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