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Hepatic PPARα is critical in the metabolic adaptation to sepsis

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Paumelle, Réjane | Haas, Joel, T | Hennuyer, Nathalie | Baugé, Eric | Deleye, Yann | Mesotten, Dieter | Langouche, Lies | Vanhoutte, Jonathan | Cudejko, Céline | Wouters, Kristiaan | Hannou, Sarah Anissa | Legry, Vanessa | Lancel, Steve | Lalloyer, Fanny | Polizzi, Arnaud | Smati, Sarra | Gourdy, Pierre | Vallez, Emmanuelle | Bouchaert, Emmanuel | Derudas, Bruno | Dehondt, Hélène | Gheeraert, Céline | Fleury, Sébastien | Tailleux, Anne | Montagner, Alexandra | Wahli, Walter | van den Berghe, Greet | Guillou, Hervé | Dombrowicz, David | Staels, Bart

Edité par CCSD ; Elsevier -

International audience. Background and aims-Although the role of inflammation to combat infection is known, the contribution of metabolic changes in response to sepsis is poorly understood. Sepsis induces the release of lipid mediators, many of which activate nuclear receptors such as the peroxisome proliferator-activated receptor (PPAR)α, which controls both lipid metabolism and inflammation. However, the role of hepatic PPARα in the response to sepsis is unknown. Methods-Sepsis was induced by intraperitoneal injection of Escherichia coli in different models of cell-specific Pparα-deficiency and their controls. The systemic and hepatic metabolic response

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