Role of biotransformation in the mutagenicity of Versicolorin A, a precursor of Aflatoxin B1

Archive ouverte

Al-Ayoubi, Carine | Oules, Justin | Person, Elodie | Bruel, Sandrine, S. | Bouville, Alyssa | Pinton, Philippe | Jamin, Emilien | Oswald, Isabelle P. | Puel, Olivier | Vettorazzi, Ariane | Soler-Vasco, Laura

Edité par CCSD -

International audience. Aflatoxin B1 (AFB1) exhibits the most severe toxicological effects of all known mycotoxins. Versicolorin A (VerA) is a precursor in the biosynthesis of AFB1. Both toxins are produced by the same aflatoxigenic species and can therefore co-contaminate food commodities. It is well established that the in vivo bioactivation of AFB1 into a highly reactive molecule is the key step in the mutagenic process. In contrast, much less is known about the toxicity of VerA and no information is available on its metabolization.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion