Gold(I)–Coumarin–Caffeine‐Based Complexes as New Potential Anti‐Inflammatory and Anticancer Trackable Agents

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Trommenschlager, Audrey | Chotard, Florian | Bertrand, Benoît | Amor, Souheila | Richard, Philippe | Bettaïeb, Ali | Paul, Catherine | Connat, Jean‐louis | Le Gendre, Pierre | Bodio, Ewen

Edité par CCSD ; Wiley-VCH Verlag -

International audience. Abstract Three new gold(I)–coumarin‐based trackable therapeutic complexes and two non‐trackable analogues have been synthesised and fully characterised. They all display anti‐proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti‐inflammatory effects; one displayed pro‐inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two‐photon microscopy.

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