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Modifications of Clostridioides difficile cell-wall. Modification de la paroi de Clostridioides difficile

Archive ouverte | Lacotte, Pierre-Alexandre | CCSD

The bacterial surface is the primary interface between the bacteria and its environment. A fundamental element of the surface, the cell wall of Clostridioides difficile (CD) is composed of peptidoglycan with which various polysacc...

La D-alanylation de la surface de Clostridioides difficile permet une résistance accrue aux antibiotiques

Archive ouverte | Lacotte, Pierre-Alexandre | CCSD

International audience. Introduction et objectifs : Clostridioides difficile (CD) est l’entéro-pathogène majoritaire des diarrhées associées aux antibiotiques et des colites pseudo-membraneuses dans le monde. Le dév...

The absence of surface D-alanylation, localized on lipoteichoic acid, impacts the Clostridioides difficile way of life and antibiotic resistance

Archive ouverte | Lacotte, Pierre-Alexandre | CCSD

International audience. D-alanylation of surface polysaccharides reduces the affinity and efficacy of cationic antimicrobial compounds (CAMPs) on the bacterial surface. In C. difficile (CD), the localization of D-al...

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