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Association of human cathelicidin (hCAP-18/LL-37) gene expression with cardiovascular disease risk factors
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International audience. Background and aims: Antimicrobial peptides (AMPs) are components of the innateimmune system. In addition, evidence suggests that these peptides are associated with variousinflammatory diseases.We examined whether expression of the cathelicidin LL-37 in peripheral bloodmononuclear cells (PBMCs) is associated with cardiovascular risk factors.Methods and results: A total of 90 men and 87 women selected from STANISLAS cohort were studied.Expression of LL-37 mRNA isolated from PBMCs of these subjects was quantified by quantitative RTPCR.Anthropometric measurements and biochemical profiles were assessed for each individual. Inwomen, LL-37 mRNA expression was significantly and positively correlated with body mass index(BMI) (p 0.001); waist circumference (WC) (p 0.01); systolic blood pressure (SBP) (p 0.05)and triglycerides (TG) level (p 0.05) and negatively with plasma levels of HDL-C (p 0.05). Inmen however, LL-37 was positively associated with waist to hip ratio (WHR) (p 0.05); SBP(p 0.001); TG (p 0.05); fasting glucose levels (p 0.01); alanine aminotransferase (ALT) activity(p 0.01); neutrophils counts (p 0.01) and negatively with lymphocyte counts (p 0.001); serumHDL-C (p 0.001) and apoA-I (p 0.05) levels. After adjustment forWC and BMI, multiple regressionanalysis showed that LL-37 remained significantly associated with SBP; HDL-C; fasting glucose level;ALT activity; neutrophil and lymphocyte counts (p 0.001 to p 0.05) in men.Conclusion: Our results suggest that LL-37 gene expression may be closely associated with cardiovascularrisk factors independently of BMI and WC. However, functional studies are required to confirmthese data.
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