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Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner
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Edité par CCSD ; National Academy of Sciences -
International audience. Significance Epidermis, the outer layer of skin, is a protective barrier and a sensing interface. Although deviation of the ambient temperature is one of the most ubiquitous stimuli affecting the skin, the influence of mild cold on epidermal homeostasis is not well understood. Using a large range of techniques, we identified a novel mild-cold sensor protein in keratinocytes and demonstrate its location in the membrane of the endoplasmic reticulum, a major calcium store of the cell, which forms a Ca 2+ -permeable ion channel. Activation of this channel links the Ca 2+ release to mitochondrial Ca 2+ uptake and, thereby, modulates synthesis of ATP and superoxide involved in control of epidermal homeostasis. Molecular inactivation of this mild-cold sensor protein in mice impairs normal epidermal homeostasis.
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