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A nanomedicine approach for the treatment of long-lasting pain

Archive ouverte | Hazam, Hadjer | CCSD

International audience. This study explores the potential of a nanomedicine approach, using Leu-enkephalin-squalene nanoparticles (LENK-SQ NPs) for managing long-lasting pain. It was observed that the nanomedicine s...

New Enkephalin Nanomedicines for Pain Alleviation, Overcoming the Side Effects of Morphine

Archive ouverte | Lepetre-Mouelhi, Sinda | CCSD

International audience. Over the last years, the nanomedicines has been recognized as a key element, capable of providing new and innovative medical solution to address unmet medical needs. More specifically, Squale...

Leu-Enkephalin Lipid Prodrug Nanoparticles: Relationship between Nanoparticles’ Structure, Interaction with Bovine Serum Albumin, and Analgesic Activity

Archive ouverte | Lepetre-Mouelhi, Sinda | CCSD

International audience. Recently, we proposed in a paper a novel nanomedicine approach based on a versatile bioconjugation linkage (amide, diglycolate, or acylal) between the Leu-enkephalin (LENK), an endogenous neu...

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