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Editorial: HF2Cancer: Exploring bidirectional interaction between cardiovascular diseases and cancer
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Edité par CCSD ; Frontiers Media -
International audience. Cardiovascular diseases (CVDs) and cancer are responsible for 50% of all deaths in middle-aged people all over the word (1). Indeed, both diseases share common risk factors, includingobesity, diabetes, lifestyle, and aging (2). They also exhibit common pathophysiological andgenetic mechanisms such as inflammation, neuro-hormonal activation, oxidative stress, clonalhematopoiesis, and a dysfunctional immune system (3). These diseases are tightly linked (4),which is supported by recent epidemiological studies and case control studies, demonstratingthat especially heart failure (HF) patients have a higher risk to develop cancer (5–9). Preclinicalstudies have shown that indeed, HF is an oncogenic stimulus (10–12), promoting tumor growthin distant organs such as the lung and colon. Furthermore, some of the cancer markers canestimate CV mortality and CVD (13).A better understanding and early diagnosis of CVD and cancer development are critical todelivering timely and targeted prevention strategies and to reduce the world healthcare economicburden. Moreover, clinical awareness is essential to optimize treatment strategies of patientshaving developed cancer with a history of CVD.In this Research Topic, we covered the expert reviews on epidemiological studies showingcancer itself leads to a higher risk of death from CVD, the novel nomogram model, somemultimodal imaging guides and cardiac biomarkers to detect or predict the risk of CVDs incancer patients, characterization of possible target molecules to prevent or treat cardiovasculardamages induced by the cancer therapy
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