Afficher la couverture 'Contribution of TRPC channels in human and experimental pulmonary arterial hypertension. Contribution of TRPC channels in human and experimental pulmonary arterial hypertension: Short title : TRPC channels in PAH | Masson, Bastien' en grand format
/5

0 avis

Contribution of TRPC channels in human and experimental pulmonary arterial hypertension. Contribution of TRPC channels in human and experimental pulmonary arterial hypertension: Short title : TRPC channels in PAH

Archive ouverte

Masson, Bastien | Saint-Martin Willer, Anais | Dutheil, Mary | Penalva, Lucille | Le Ribeuz, Hélène | El Jekmek, Kristelle | Ruchon, Yann | Cohen-Kaminsky, Sylvia | Sabourin, Jessica | Humbert, Marc | Mercier, Olaf | Montani, David | Capuano, Véronique | Antigny, Fabrice

Edité par CCSD ; American Physiological Society -

International audience. TRPC3 is increased in human and experimental pulmonary arterial hypertension (PAH). In PAH pulmonary arterial smooth muscle cells, TRPC3 participates in the aberrant store-operated Ca 2+ entry contributing to their pathological cell phenotypes (exacerbated proliferation, enhanced migration, apoptosis resistance, and vasoconstriction). Pharmacological in vivo inhibition of TRPC3 reduces the development of experimental PAH. Even if other TRPC acts on PAH development, our results prove that TRPC3 inhibition could be considered as an innovative treatment for PAH.

Suggestions

Du même auteur

Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension

Archive ouverte | Masson, Bastien | CCSD

International audience. Rationale: Pulmonary arterial hypertension (PAH) is characterized by progressive distal pulmonary artery (PA) obstruction, leading to right ventricular hypertrophy and failure. Exacerbated in...

Involvement of SUR2/Kir6.1 channel in the physiopathology of pulmonary arterial hypertension

Archive ouverte | Le Ribeuz, Hélène | CCSD

International audience. Aims: We hypothesized that the ATP-sensitive K+ channels (KATP) regulatory subunit (ABCC9) contributes to PAH pathogenesis. ABCC9 gene encodes for two regulatory subunits of KATP channels: th...

SUR1 as a new therapeutic target for pulmonary arterial hypertension

Archive ouverte | Le Ribeuz, Hélène | CCSD

International audience. Mutations in ABCC8 have been identified in pulmonary arterial hypertension (PAH). ABCC8 encodes SUR1, a regulatory subunit of the ATP-sensitive potassium channel Kir6.2. However, the pathophy...

Chargement des enrichissements...