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Molecular Mechanism of Nucleosome Recognition by the Pioneer Transcription Factor Sox

Archive ouverte | Ozden, Burcu | CCSD

International audience. Pioneer transcription factors (PTFs) have the remarkable ability to directly bind to chromatin to stimulate vital cellular processes. In this work, we dissect the universal binding mode of So...

Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends

Archive ouverte | Boopathi, Ramachandran | CCSD

International audience. The histone H3 variant CENP-A marks centromeres epigenetically and is essential for mitotic fidelity. Previous crystallographic studies of the CENP-A nucleosome core particle (NCP) reconstitu...

The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly

Archive ouverte | Kale, Seyit | CCSD

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Chargement des enrichissements...