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CK2β-regulated signaling controls B cell differentiation and function

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Quotti Tubi, Laura | Mandato, Elisa | Canovas Nunes, Sara | Arjomand, Arash | Zaffino, Fortunato | Manni, Sabrina | Casellato, Alessandro | Macaccaro, Paolo | Vitulo, Nicola | Zumerle, Sara | Filhol, Odile | Boldyreff, Brigitte | Siebel, Christian, W | Viola, Antonella | Valle, Giorgio | Mainoldi, Federica | Casola, Stefano | Cancila, Valeria | Gulino, Alessandro | Tripodo, Claudio | Pizzi, Marco | Dei Tos, Angelo, Paolo | Trentin, Livio | Semenzato, Gianpietro | Piazza, Francesco

Edité par CCSD ; Frontiers -

International audience. frequency in CK2b KO mice suggesting the importance of the b subunit in sustaining antibody affinity maturation. Lastly, since diffuse large B cell lymphoma (DLBCL) cells derive from GC or post-GC B cells and rely on CK2 for their survival, we sought to investigate the consequences of CK2 inhibition on B cell signaling in DLBCL cells. In line with the observations in our murine model, CK2 inactivation leads to signaling defects in pathways that are essential for malignant B-lymphocyte activation.

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