Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

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Zbili, Mickaël | Rama, Sylvain | Benitez, Maria-José | Fronzaroli-Molinieres, Laure | Bialowas, Andrzej | Boumedine-Guignon, Norah | Garrido, Juan José | Debanne, Dominique

Edité par CCSD ; National Academy of Sciences -

International audience. Significance The mechanisms linking homeostatic regulation of synaptic transmission to homeostatic regulation of intrinsic excitability are poorly understood. We show here that chronic blockade of excitatory synaptic receptors in the CA3 area induces an up-regulation of both synaptic transmission and intrinsic excitability. Enhanced excitability was found to result from a reduction in Kv1.1 channel density at the axon initial segment. In parallel, enhanced synaptic transmission was largely due to a loss of presynaptic Kv1.1 function. We conclude that the regulation of axonal Kv1.1 channels constitutes a significant mechanism linking homeostatic regulation of synaptic transmission and homeostatic regulation of intrinsic excitability in CA3 circuits.

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