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Continuous MYD88 Activation Is Associated With Expansion and Then Transformation of IgM Differentiating Plasma Cells

Archive ouverte | Ouk, Catherine | CCSD

International audience. Activating mutations of MYD88 ( MYD88 L265P being the far most frequent) are found in most cases of Waldenström macroglobulinemia (WM) as well as in various aggressive B-cell lymphoma entitie...

REL deregulation stands as a primary hit for AID-imprinted B-cells along the germinal center competition

Archive ouverte | Prévaud, Léa | CCSD

Abstract In diffuse large B-cell lymphomas (DLBCLs), gains and amplifications of the 2p15-16 region, which always encompass the REL gene, are mostly restricted to the germinal center (GC) B- cell DLBCL subtype (GCB-DLBCL) for whic...

REL deregulation stands as a primary hit for AID-imprinted B-cells along the germinal center competition

Archive ouverte | Prévaud, Léa | CCSD

In diffuse large B-cell lymphomas (DLBCLs), gains and amplifications of the 2p15-16 region, which always encompass the REL gene, are mostly restricted to the germinal center (GC) B- cell DLBCL subtype (GCB-DLBCL) for which c-Rel i...

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