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A Small Tau Fragment Specifically Templates Four Repeat Tau Aggregates Through Multiple Generations

Archive ouverte | Longhini, Andrew | CCSD

Prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. A 19-residue probe peptide containing a P301L mutation and spanning the R2/R3 splice junction of tau, folds and stacks into seeding-competent f...

A Small Tau Fragment Specifically Templates Four Repeat Tau Aggregates Through Multiple Generations

Archive ouverte | Longhini, Andrew | CCSD

Summary Prion-like spread of disease-specific tau conformers is a hallmark of all tauopathies. We used a 19-residue probe peptide spanning the R2/R3 splice junction of tau to induce aggregation specifically of 4R, but not 3R tau. ...

Mutations in tau protein promote aggregation by favoring extended conformations

Archive ouverte | Pounot, Kevin | CCSD

Amyloid aggregation of the intrinsically disordered protein (IDP) tau is involved in several diseases, called tauopathies. Some tauopathies can be inherited due to mutations in the gene encoding tau, which might favor the formatio...

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