Strict tropism for CD71$^+$/CD234$^+$ human reticulocytes limits the zoonotic potential of $Plasmodium\ cynomolgi$

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Kosaisavee, Varakorn | Suwanarusk, Rossarin | Chua, Adeline, C Y | Kyle, Dennis, E | Malleret, Benoit | Zhang, Rou | Imwong, Mallika | Imerbsin, Rawiwan | Ubalee, Ratawan | Sámano-Sánchez, Hugo | Yeung, Bryan, K S | Ong, Jessica, J Y | Lombardini, Eric | Nosten, François | Tan, Kevin, S W | Bifani, Pablo | Snounou, Georges | Rénia, Laurent | Russell, Bruce

Edité par CCSD ; American Society of Hematology -

International audience. Two malaria parasites of Southeast Asian macaques, Plasmodium knowlesi and P cynomolgi, can infect humans experimentally. In Malaysia, where both species are common, zoonotic knowlesi malaria has recently become dominant, and cases are recorded throughout the region. By contrast, to date, only a single case of naturally acquired P cynomolgi has been found in humans. In this study, we show that whereas P cynomolgi merozoites invade monkey red blood cells indiscriminately in vitro, in humans, they are restricted to reticulocytes expressing both transferrin receptor 1 (Trf1 or CD71) and the Duffy antigen/chemokine receptor (DARC or CD234). This likely contributes to the paucity of detectable zoonotic cynomolgi malaria. We further describe postinvasion morphologic and rheologic alterations in P cynomolgi–infected human reticulocytes that are strikingly similar to those observed for P vivax. These observations stress the value of P cynomolgi as a model in the development of blood stage vaccines against vivax malaria

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