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Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia Ex Vivo : Potentials and Pitfalls

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Dembélé, Laurent | Franetich, Jean-François | Soulard, Valérie | Amanzougaghene, Nadia | Tajeri, Shahin | Bousema, Teun | van Gemert, Geert-Jan | Le Grand, Roger | Dereuddre-Bosquet, Nathalie | Baird, J. Kevin | Mazier, Dominique | Snounou, Georges

Edité par CCSD ; American Society for Microbiology -

International audience. For a long while, 8-aminoquinoline compounds have been the only therapeutic agents against latent hepatic malaria parasites. These have poor activity against the blood-stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of Plasmodium cynomolgi , Plasmodium yoelii , Plasmodium berghei , and Plasmodium falciparum within several ex vivo systems—primary hepatocytes of Macaca fascicularis , primary human hepatocytes, and stably transformed human hepatocarcinoma cell line HepG2.

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