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Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues

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Malikidogo, Kyangwi | Isaac, Manon | Uguen, Adrien | Même, Sandra | Pallier, Agnès | Clémençon, Rudy | Morfin, Jean-François | Lacerda, Sara | Tóth, Éva | Bonnet, Célia

Edité par CCSD ; Royal Society of Chemistry -

International audience. We present the in vitro characterisation of a Gd3+-based contrast agent that responds to Zn2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd3+-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents.

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