Surgery for Primary Aldosteronism in France From 2010 to 2020 – Results from the French-Speaking Association of Endocrine Surgery (AFCE)

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Vignaud, Timothée | Baud, Grégory | Nominé-Criqui, Claire | Donatini, Gianluca | Santucci, Nicolas | Hamy, Antoine | Lifante, Jean-Christophe | Maillard, Laure | Mathonnet, Muriel | Chereau, Nathalie | Pattou, François | Caiazzo, Robert | Tresallet, Christophe | Kuczma, Paulina | Ménégaux, Fabrice | Drui, Delphine | Gaujoux, Sébastien | Brunaud, Laurent | Mirallié, Eric

Edité par CCSD ; Lippincott, Williams & Wilkins -

International audience. Objective: Describe the diagnostic workup and postoperative results for patients treated by adrenalectomy for primary aldosteronism in France from 2010 to 2020 Background: Primary aldosteronism (PA) is the underlying cause of hypertension in 6% to 18% of patients. French and international guidelines recommend CT-scan and adrenal vein sampling as part of diagnostic workup to distinguish unilateral PA amenable to surgical treatment from bilateral PA that will require lifelong antialdosterone treatment. Adrenalectomy for unilateral primary aldosteronism has been associated with complete resolution of hypertension (no antihypertensive drugs and normal ambulatory blood pressure) in about one-third of patients and complete biological success in 94% of patients. These results are mainly based on retrospective studies with short follow-up and aggregated patients from various international high-volume centers. Methods: Here we report results from the French-Speaking Association of Endocrine Surgery (AFCE) using the Eurocrine® Database. Results: Over 11 years, 385 patients from 10 medical centers were eligible for analysis, accounting for >40% of adrenalectomies performed in France for primary aldosteronism over the period. Preoperative workup was consistent with guidelines for 40% of patients. Complete clinical success (CCS) at the last follow-up was achieved in 32% of patients, and complete biological success was not sufficiently assessed. For patients with 2 follow-up visits, clinical results were not persistent at 1 year for one-fifth of patients. Factors associated with CCS on multivariate analysis were body mass index, duration of hypertension, and number of antihypertensive drugs. Conclusions: These results call for an improvement in thorough preoperative workup and long-term follow-up of patients (clinical and biological) to early manage hypertension and/or PA relapse.

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