NMR-based metabolomics studies to investigate TNAP (tissue-nonspecific alkaline phosphatase) functions in brain and liver

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Balayssac, Stéphane | Drevet Mulard, Eva | Nowak, Lionel, G | Briolay, Anne | Bessueille, Laurence | J. P. Rautureau, Gilles | Magne, David | Fonta, Caroline | Gilard, Véronique

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International audience. TNAP (Tissue Non-specific Alkaline Phosphatase) is an enzyme that belongs to the family of alkaline phosphatases. TNAP is expressed in various tissues including bone, kidney, brain and liver. Dysregulation of TNAP activity leads to hypophosphatasia, a rare genetic human disorder associated with altered bone formation and neurodevelopmental disorders. In bone, TNAP is involved in mineralization processes through PPi regulation. In the brain, TNAP plays a crucial role in neuronal development and functioning through the metabolism of pyridoxal phosphate, the active form of vitamin B6, and the control of extracellular nucleotide level. In contrast, the functions of TNAP in the liver remain obscure. It is thought to be involved in bile acid metabolism and excretion, contributing to the digestion and absorption of dietary fats and fat-soluble vitamins. Previous studies conducted by our consortium support the role of TNAP in brain [1] and hepatic functions [2].,This poster summarizes NMR-based metabolomics studies we have recently designed to gain a deeper understanding of the functions of TNAP in the brain and liver.

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