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Discovery of an Active RAG Transposon Illuminates the Origins of V(D)J Recombination

Archive ouverte | Huang, Shengfeng | CCSD

International audience. Co-option of RAG1 and RAG2 for antigen receptor gene assembly by V(D)J recombination was a crucial event in the evolution of jawed vertebrate adaptive immunity. RAG1/2 are proposed to have ar...

Amphioxus functional genomics and the origins of vertebrate gene regulation

Archive ouverte | Marletaz, Ferdinand | CCSD

International audience. Vertebrates have greatly elaborated the basic chordate body plan and evolved highly distinctive genomes that have been sculpted by two whole-genome duplications. Here we sequence the genome o...

Insights into RAG evolution from the identification of “missing link” family A RAGL transposons

Archive ouverte | Martin, Eliza, C | CCSD

International audience. ABSTRACT A series of “molecular domestication” events are thought to have converted an invertebrate RAG-like (RAGL) transposase into the RAG1-RAG2 (RAG) recombinase, a critical enzyme for ada...

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