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A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally.

Archive ouverte | Mazuc, Elsa | CCSD

International audience. BACKGROUND: The spleen tyrosine kinase (Syk) is recognized as a potential pharmaceutical target for the treatment of type I hypersensitivity reactions including allergic rhinitis, urticaria, ...

Prostaglandin D2 Inhibits the Production of IFN-γ by Invariant NK T Cells: Consequences in the Control of B16 Melanoma

Archive ouverte | Torres, David | CCSD

International audience. Abstract Invariant NK T (iNKT) cells are a subset of innate/memory lymphocytes that recognize lipid Ags presented by CD1d-expressing APCs such as dendritic cells (DCs). Upon primary stimulati...

Activation of invariant NKT cells by the helminth parasite schistosoma mansoni

Archive ouverte | Mallevaey, Thierry | CCSD

Mouse CD1d-restricted NKT cells, including invariant (i)NKT cells, are innate cells activated by glycolipid Ags and play important roles in the initiation and regulation of immune responses. Through their ability to promptly produ...

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