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Proliferation impairment of chondrosarcoma cells irradiated with X-Rays and carbon-ion beams

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Chevalier, François | Hamdi, Dounia, Houria | Jong, Yvonne De | Bovée, Judith V. M. G.. | Saintigny, Yannick

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International audience. Chondrosarcoma is a malignant tumor arising from cartilaginous tissues, described as radiation- and chemo- resistant to conventional treatments. The primary treatment consists in wide surgical resection, which may lead to severe disabilities; in addition, this procedure is not feasible for some inoperable locations such as skull base chondrosarcoma. Carbon-ion irradiation (hadron-therapy) has been successfully used in the treatment of chondrosarcoma, due notably to a higher biological effectiveness and a better ballistic as compared with conventional radiotherapy with X-Rays. Aim of this study- explore the differential cellular responses of chondrosarcomas to conventional radiotherapy and hadrontherapy- understand the biological effects of carbon beams in cancer treatment. - estimate the capacity of PARP-1 inhibitor in radio-sensitizing chondrosarcoma cells

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