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U2AF65 assemblies drive sequence-specific splice site recognition

Archive ouverte | Tari, Manel | CCSD

International audience. The essential splicing factor U2AF65 is known to help anchoring U2 snRNP at the branch site. Its C-terminal UHM domain interacts with ULM motifs of SF3b155, an U2 snRNP protein. Here, we repo...

Identification of a small molecule splicing inhibitor targeting UHM domains

Archive ouverte | Kobayashi, Asaki | CCSD

International audience. Splicing factor mutations are frequent in myeloid neoplasms, blood cancers,and solid tumors. Cancer cells harboring these mutations present aparticular vulnerability to drugs that target spli...

TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm

Archive ouverte | Rabhi, Célia | CCSD

International audience. Protein aggregation is a hallmark of many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), in which TDP-43, a nuclear RNA-binding protein, forms cytoplasmic inclusi...

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