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Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa

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Bour, Maxime | Fournier, Damien | Jové, Thomas | Pouzol, Armelle | Miltgen, Guillaume | Janvier, Frédéric | Jeannot, Katy | Plésiat, Patrick

Edité par CCSD ; American Society for Microbiology -

International audience. Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor the gene encoding the rare class C β-lactamase PAC-1 on a chromosomally located Tn 1721 -like transposon. The bla PAC-1 gene was associated with the 16S rRNA methylase determinant rmtF2 , which confers pan-aminoglycoside resistance.

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