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The senotherapeutic drug ABT-737 disrupts aberrant p21 expression to restore liver regeneration in adult mice

Archive ouverte | Ritschka, Birgit | CCSD

International audience. Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver r...

Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning

Archive ouverte | Riba, Andrea | CCSD

International audience. Abstract Despite the fact that the cell cycle is a fundamental process of life, a detailed quantitative understanding of gene regulation dynamics throughout the cell cycle is far from complet...

Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription

Archive ouverte | Wang, Fang | CCSD

International audience. Co-activator complexes dynamically deposit post-translational modifications (PTMs) on histones, or remove them, to regulate chromatin accessibility and/or to create/erase docking surfaces for...

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