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Base excision repair of 8-oxoG in dinucleosomes

Archive ouverte | Menoni, Hervé | CCSD

In this work we have studied the effect of chromatin structure on the base excision repair (BER) efficiency of 8-oxoG. As a model system we have used precisely positioned dinucleosomes assembled with linker histone H1. A single 8-...

The NH2 tail of the novel histone variant H2BFWT exhibits properties distinct from conventional H2B with respect to the assembly of mitotic chromosomes.

Archive ouverte | Boulard, Matthieu | CCSD

International audience. We have studied the functional and structural properties of nucleosomes reconstituted with H2BFWT, a recently identified putative histone variant of the H2B family with totally unknown functi...

Single-base resolution mapping of H1-nucleosome interactions and 3D organization of the nucleosome

Archive ouverte | Syed, Sajad Hussain | CCSD

Despite the key role of the linker histone H1 in chromatin structure and dynamics, its location and interactions with nucleosomal DNA have not been elucidated. In this work we have used a combination of electron cryomicroscopy, hy...

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