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ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition

Archive ouverte | Kemps, Paul Geraeds | CCSD

International audience. ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in 3 infants with multisystemic disease involving the liver and hematopoietic system. This entity ...

Risk of Second Cancer in Erdheim-Chester Disease

Archive ouverte | Pegoraro, Francesco | CCSD

International audience. This cohort study analyzes the risk of second cancers in a cohort of 515 patients with Erdheim-Chester disease followed up at 2 histiocytosis centers in France and Italy.

The contribution of micrornas to the inflammatory and neoplastic characteristics of erdheim–chester disease

Archive ouverte | Weissman, Ran | CCSD

International audience. The pathogenesis of histiocytic neoplasms is driven by mutations activating the MAPK/ERK pathway, but little is known about the transcriptional and post-transcriptional alterations involved i...

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