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Schwann cells support oncogenic potential of pancreatic cancer cells through TGFβ signaling

Archive ouverte | Roger, Elodie | CCSD

International audience. Pancreatic ductal adenocarcinoma (PDAC) is one of the solid tumors with the poorest prognosis. The stroma of this tumor is abundant and composed of extracellular matrix and stromal cells (inc...

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4

Archive ouverte | Bertrand-Chapel, Adrien | CCSD

International audience. TGF-β signaling is involved in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis, representing one of the four major pathways genetically altered in 100% of PDAC cases. TGF-β exerts compl...

Histopronostic factors in superficial colorectal adenocarcinomas treated by endoscopy: reproducibility and impact of immunohistochemistry and digital pathology

Archive ouverte | Pontarollo, Guillaume | CCSD

International audience. Abstract Endoscopic dissection is the first-choice treatment for superficial pT1 colorectal adenocarcinoma (sCRC). Complementary surgery decision is influenced by histopronostic factors. Prog...

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