Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes
Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response
Archive ouverte
| Lahlali, Thomas | CCSD
International audience.
Background & AimsNetrin-1, a multifunctional secreted protein, is up-regulated in cancer and inflammation. Netrin-1 blocks apoptosis induced by the prototypical dependence receptors deleted i...
Hepatic inflammation elicits production of proinflammatory netrin‐1 through exclusive activation of translation
Archive ouverte
| Barnault, Romain | CCSD
International audience.
Background and Aims: Netrin‐1 displays protumoral properties, though the pathological contexts and processes involved in its induction remain understudied. The liver is a major model of infla...
